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In International Conference on Hybrid Artificial Intelligence Systems , vol
BMJ 379:e071050 Petschner P, Gonda X, Baksa D, Eszlari N, Trivaks M, Juhasz G, Bagdy G (2018) Genes linking mitochondrial function, cognitive impairment and depression are associated with endophenotypes serving precision medicine
These outcomes lead to the remodeling of the extracellular matrix, oxidative stress, inflammation, cardiomyocyte apoptosis, fibrosis, and metabolic abnormalities [55]
Besides, in H9c2 cardiomyocytes, GLP-1RAs also inhibit hypoxia-induced NLRP3 inflammasome activity and TNF- to attenuate pyroptosis through modulating the SIRT1/NADPH oxidase 4 (NOX4)/ROS pathway [139]
10.1136/bmj.d4169 183
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